Is bisphosphonate therapy for benign bone
disease associated with impaired dental healing?
A case-controlled study
Works Cited:
References
Borromeo, G. L., Brand, C., Clement, J. G., McCullough, M., Thomson, W., Flitzanis, E., & Wark, J. D. (2011). Is bisphosphonate therapy for benign bone disease associated with impaired dental healing? A case-controlled study. BMC Musculoskeletal Disorders, 12(1), 71-80.doi:10.1186/1471-2474-12-71
Summary of journal article:
This article discusses problems associated with long term use of bisphosphonates for the treatment of osteoporosis. Bisphosphonates are non-metabolized analogues of pyrophosphates that can be given in a less potent form such as alendronate and risedronate and are a first-line therapy for the treatment of post-menopausal osteoporosis. There are several recent reports showing a possible association between bisphosphonate use and jaw osteonecrosis. The exact mechanism by which bisphosphonates may contribute to impaired resistance to injury or impaired healing of the maxilla or mandible and to osteolytic destruction, remains unclear. However, suppression of bone turnover via actions on osteoclasts seems to play a substantial role (Pract, 2006, page 2). In this study researchers tested the hypothesis that long-term, more than a year, use of bisphosphonate for the treatment of osteoporosis is associated with impaired dental healing. Researchers believe that the bisphosphonates delay the dental healing after either spontaneous dental trauma or after dental procedures such as tooth extractions, implant placement, or denture use.
I believe an article like this will help me with my dental hygiene care because I now know that a patient with osteoporosis will likely be taking bisphosphonates and will also likely have delayed dental healing. This could effect treatment planning for the patient as well as the hygienist needing to keep a close eye on any areas in the patients mouth that have either had trauma or dental treatment.
Personal Reflection:
I chose to do this condition because my best friend's mom has osteoporosis. I know that she has to take daily medication for the condition, and after reading this article I am curious what medications she is on. I will be sending her a link to this article because I think it has a lot of good information and I'm curious if she knows about these side effects. Also, when we were going over the risk factors in class for osteoporosis it seemed like I have a lot of them, so I thought it would be nice to learn a little bit more about the condition in case I someday have to deal with it.
Additional Information:
http://www.youtube.com/watch?v=rHyeZhcoZcQ
http://www.youtube.com/watch?v=HqHfejgoJDw
References
Borromeo, G. L., Brand, C., Clement, J. G., McCullough, M., Thomson, W., Flitzanis, E., & Wark, J. D. (2011). Is bisphosphonate therapy for benign bone disease associated with impaired dental healing? A case-controlled study. BMC Musculoskeletal Disorders, 12(1), 71-80.doi:10.1186/1471-2474-12-71
Summary of journal article:
This article discusses problems associated with long term use of bisphosphonates for the treatment of osteoporosis. Bisphosphonates are non-metabolized analogues of pyrophosphates that can be given in a less potent form such as alendronate and risedronate and are a first-line therapy for the treatment of post-menopausal osteoporosis. There are several recent reports showing a possible association between bisphosphonate use and jaw osteonecrosis. The exact mechanism by which bisphosphonates may contribute to impaired resistance to injury or impaired healing of the maxilla or mandible and to osteolytic destruction, remains unclear. However, suppression of bone turnover via actions on osteoclasts seems to play a substantial role (Pract, 2006, page 2). In this study researchers tested the hypothesis that long-term, more than a year, use of bisphosphonate for the treatment of osteoporosis is associated with impaired dental healing. Researchers believe that the bisphosphonates delay the dental healing after either spontaneous dental trauma or after dental procedures such as tooth extractions, implant placement, or denture use.
I believe an article like this will help me with my dental hygiene care because I now know that a patient with osteoporosis will likely be taking bisphosphonates and will also likely have delayed dental healing. This could effect treatment planning for the patient as well as the hygienist needing to keep a close eye on any areas in the patients mouth that have either had trauma or dental treatment.
Personal Reflection:
I chose to do this condition because my best friend's mom has osteoporosis. I know that she has to take daily medication for the condition, and after reading this article I am curious what medications she is on. I will be sending her a link to this article because I think it has a lot of good information and I'm curious if she knows about these side effects. Also, when we were going over the risk factors in class for osteoporosis it seemed like I have a lot of them, so I thought it would be nice to learn a little bit more about the condition in case I someday have to deal with it.
Additional Information:
http://www.youtube.com/watch?v=rHyeZhcoZcQ
http://www.youtube.com/watch?v=HqHfejgoJDw